Regenerative Medicine and Plastic Surgery.Ordinary and Activated Bone Substitutes

Bone substitutes are highly demanded in clinical practice for grafting of bone defects and alveolar ridge augmentation. Based on the analysis of modern groups of bone substitutes, particularities of their composition, mechanisms of biological effects, and therapeutic indications, applicable classification was proposed which consisted of separation of these materials to “ordinary” and “activated.” The main differential criterion is a presence of biologically active components in the material which are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructs encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated bone substitutes allow to draw upon their efficacy in substitution of large bone defects.

Bozo, Ilya Y., (et al.) Regenerative Medicine and Plastic Surgery.Ordinary and Activated Bone Substitutes. DOI 978-3-030-19962-3_14, © 2019
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